On October 4, 1925 Miss Helen Schoedinger was engaged as Director of Religious Education, a position which she held until May 13, 1931 when she resigned because of the ill health of her mother.

Ladies' and men's organizations were active in support of the church, providing fellowship and serving mission. An active Men's Brotherhood sponsored the annual Brotherhood Banquet which, because of the location of the church near the Franklin County offices and the downtown business and civic centers, became one of the more popular annual community events, the dining room overflowing with distinguished visitors and guests.

The annual Sunday School picnics were a special event. Hundreds of children, teachers, church members and friends marched down High Street in costumes and riding decorated wagons, bicycles and motor vehicles to Schiller Park. Barrels of lemonade were consumed and all sorts of food, games and contests were enjoyed. A band concert and worship service would end the festivities of the day. It is recorded that 2,500 persons attended the picnic in 1930.

St. John's sponsored Boy Scout and Girl Scout troops and athletic teams, particularly bowling and basketball. City League trophies were won by St. John's teams throughout the 1920's and in 1930.

After seventeen years of service at St. John's Rev. Lehmann resigned in January 1928 to become the president of Elmhurst College. On October 23, 1928 the Rev. Gottieb Siegenthaler was installed as the sixth pastor of St. John's.

With membership peaking in 1929 at 1,727, the church, as the world, was about to enter into the period known as the Great Depression. Yet, during the worst of these years, almost $50,000 was paid on the debt for the new church building. The mortgage to Franklin Savings and Loan was burned on September 25, 1932, leaving an indebtedness of $36,000 in bonds owned largely by members of the congregation.

The union of the Evangelical Synod and the Reformed Church was consummated June 26, 1934. The name of the new body was the Evangelical and Reformed Church.

With the church membership now at 1,527, Rev. Siegnthaler resigned in January 1935 to assume the pastorate of St. Matthew's in Baltimore. A call was made to Rev. Arnold E. Klick. He was installed September 22, 1935.

A note-burning ceremony took place June 15, 1941 due, in great measure, to the untiring efforts of Mr Robert Rausch, in his capacity as treasurer of the congregation for four years, and president of the congregation for two years.

Others would serve the church at this time. Adolph Baer, Superintendent of the Sunday School for 28 years, died in 1943. Charles Lucks assumed the position, serving until 1951. In 1946 Rev. Paul Kiewit was called as associate pastor and assumed his duties on September 1, 1946. Rev. Mary Lou Bischman was called as assistant pastor from 1951 to1954. Mrs. Lillian Baer Kroff served the duties of Superintendent of the Sunday School 1951 to 1953.

Above the altar is a large carved wood sculpture. This piece, called a reredos (from the Latin for "back" or "behind"), was carved in Germany from walnut and installed in the church in 1953 as a memorial to Mrs. George Reibel from her husband. A new organ was also installed at this time at a cost of $38,000.

Rev. Klick resigned in December 1953 to enter the national mission field by starting the congregation of Western Hills, Omaha, Nebraska. The Rev. Arthur Detwiler was installed on September 13, 1954. In 1957 St. John's called Rev. Ralph E. Schluer to become the associate pastor.

The merger of the Evangelical and Reformed Church and the Congregational Christian Churches had been completed in 1957, forming the United Church of Christ. The Uniting General Synod of the United Church of Christ met on June 26, 1958.

In 1959 Rev. Detwiller resigned in October to accept a call in Texas. Mrs. Elmer Krauss became Superintendent of the Sunday School and served into 1962.

Rev. Schluer was called to become Senior Pastor of St. John's in May 1960. In that same year, by amendment to the Constitution of St. John's, the Board of Christian Education was created. Also the first women were elected to Consistory, two being elected to be deacons.

Pastor William F. von Brauchitsch was called to be the Associate Pastor and installed on December 3, 1961.

In 1962 Carl Hingst became the Sunday School Superintendent. On November 14, 1962, Pastor Ralph Schluer died while serving as Senior Pastor of St. John's at the age of 51. Then, on Palm Sunday, April 7, 1963, "the dream of our founders" -- what was called "the Chapel" (Christian Education Building) -- was partially destroyed by fire. Pastor Leroy Kutz, Jr. was called to the Senior Pastor position and began his ministry July 7, 1963. On August 18, 1963 Martha Teeters was commissioned to full-time ministry in the United Church of Christ.

After a settlement with the insurance company for fire damage, plans were made to rebuild the Christian Education Building. The grand total of pledges reported by March 29, 1964 was $186,916.30. George Stegmiller was the architect and Garwick & Ross the general contractors for the new building. The ground-breaking service was held on September 13, with Dr. Timothy Lehmann as speaker. Don Weatherby became the Superintendent of the Sunday School.

Three services in 1965 would mark the progress of building of the new Christian Education Building. On February 28 came the Reichtfest (topping ceremony); on Palm Sunday, April 11, the cornerstone laying; and September 12, the dedication.

On July 13, 1968, John and Marjorie Steva and family left to serve as missionaries to Honduras. A year later the Young Adult Fellowship begun a project to raise money to ship a large number of farm animals to the Steva Mission.

In 1966 was the introduction of the Triune Concert Series, a musical mission to the community featuring central Ohio musicians. May Schwarz was called to be the Minister of Music of St. John's Church in 1969. After more than 34 years May is still serving St. John's and the community with her gift of music. Under her leadership, St. John's has become well known as one of the premier church music ministries in Columbus, and its music program is the hallmark by which St. John's is known in the Columbus area. In 2003 she was honored as one of the oustanding music ministers in the country.

1966 also saw the dedication of the library-lounge, installation of the carillon, and, with the leadership of Arthur and Fay Welch and associate pastor William von Brauchitsch, the organization of the Senior Christian Fellowship.

On October 14, 1986 Pastor von Brauchitsch resigned as associate pastor, effective December 31, 1968. Pastor Bill, as he was known, would become Pastor of Evangelism, a part-time position, on August 31, 1969. He died in June, 2000 at the age of 97.

Renovation of the sanctuary and construction of a narthex began in April 1971 and was completed in June. That summer and fall funds were raised for the Development Fund of United Church Homes, Inc.

Pastor Kutz resigned his position as Senior Pastor to accept a call to serve as Senior Minister of First Congregational Church of Port Huron, Michigan, on September 30,1973.

On June 16, 1974 Rev. Donald W Gorbett began his ministry as senior pastor. Upon his resignation Pastor Paul E. Baumer was called to ministry

During the 1980's, like many churches in downtown Columbus, the congregation began a long-term decline in membership. Nonetheless the sanctuary was refurbished during the summer of 1987 and an elevator was added to the building in 1995. The congregation has entered into several community ministries including ministries with homeless families, in 1986 becoming a partner in Open Church, and in 1995 becoming a partner with First AME Zion Church in the Interfaith Hospitality Network. The congregation participated in the Downtown Council of Churches.

In 2002, Barbara McClure retired as Sunday School superintendant after serving in that capacity for 27 years.